Type I iodothyronine deiodinase is a selenocysteine-containing enzyme

  title={Type I iodothyronine deiodinase is a selenocysteine-containing enzyme},
  author={Maria J. Berry and Laila Banu and P. R. Larsen},
ALTHOUGHthyroxine (3,5,3',5'-tetraiodothyronine, T4) is the principal secretory product of the vertebrate thyroid, its essential metabolic and developmental effects are all mediated by 3,5,3'-triiodothyronine (T3), which is produced from the prohormone by 5'-deiodination. The type-I iodothyronine deiodinase, a thiol-requiring propylthiouracil-sensitive oxidoreductase, is found mainly in liver and kidney and provides most of the circulating T3 1 but so far this enzyme has not been purified… CONTINUE READING
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