Type I interferons in host defense.

@article{Stetson2006TypeII,
  title={Type I interferons in host defense.},
  author={Daniel B. Stetson and Ruslan Medzhitov},
  journal={Immunity},
  year={2006},
  volume={25 3},
  pages={
          373-81
        }
}
Type I interferons (IFNs) are a family of cytokines specialized to coordinate immunity to viruses and other intracellular infections. In the past several years, many of the receptors and signaling pathways that link pathogen detection to induction of type I IFNs have been identified and characterized. An integrated picture has emerged in which type I IFNs have essential functions in several seemingly disparate processes: they restrict viral spread by engaging machinery that ultimately cripples… CONTINUE READING
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