Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection

@inproceedings{Srivastava2014TypeII,
  title={Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection},
  author={Shivani Srivastava and Meghan Anne Koch and Marion Pepper and Daniel J Campbell},
  booktitle={The Journal of experimental medicine},
  year={2014}
}
Regulatory T (T reg) cells play an essential role in preventing autoimmunity but can also impair clearance of foreign pathogens. Paradoxically, signals known to promote T reg cell function are abundant during infection and could inappropriately enhance T reg cell activity. How T reg cell function is restrained during infection to allow the generation of effective antiviral responses remains largely unclear. We demonstrate that the potent antiviral type I interferons (IFNs) directly inhibit co… CONTINUE READING
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