Type-I interferons are potent inhibitors of interleukin-8 production in hematopoietic and bone marrow stromal cells.

@article{Aman1993TypeIIA,
  title={Type-I interferons are potent inhibitors of interleukin-8 production in hematopoietic and bone marrow stromal cells.},
  author={M Javad Aman and Gabrielle Rudolf and Jutta Goldschmitt and Walter Erich Aulitzky and Chi-tat Lam and Christoph Huber and Christian Peschel},
  journal={Blood},
  year={1993},
  volume={82 8},
  pages={2371-8}
}
Interleukin-8 (IL-8) is produced by many cell types upon stimulation with bacterial products or inflammation-associated cytokines such as tumor necrosis factor-alpha and IL-1. Interferons (IFNs) represent another group of cytokines that are induced by similar stimuli in inflammatory reactions. We show now that type-I IFNs are potent inhibitors of IL-8 expression in vitro and in vivo. A significant reduction of both secretion of IL-8 protein and accumulation of IL-8 mRNA in vitro was observed in… CONTINUE READING
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