Type I interferons are not critical for skin allograft rejection or the generation of donor-specific CD8+ memory T cells.

Abstract

Type I interferons (IFN-I) link innate to adaptive immunity in microbial infection, autoimmune disease and tumor immunity. It is not known whether IFN-I have an equally central role in alloimmunity. Here we tested this possibility by studying skin allograft survival and donor-specific CD8+ T-cell responses in mice that lack the IFN-I receptor (IFN-IR… (More)
DOI: 10.1111/j.1600-6143.2009.02871.x

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