Type I interferons are involved in the development of ultraviolet B-induced inflammatory skin lesions in systemic lupus erythaematosus patients.

@article{Reefman2008TypeII,
  title={Type I interferons are involved in the development of ultraviolet B-induced inflammatory skin lesions in systemic lupus erythaematosus patients.},
  author={Esther Reefman and Hilde Kuiper and Pieter C. Limburg and Cees G. M. Kallenberg and M. H. de Bijl},
  journal={Annals of the rheumatic diseases},
  year={2008},
  volume={67 1},
  pages={11-18}
}
OBJECTIVE To investigate the involvement of type I interferons and endothelial cell adhesion molecules in the development of ultraviolet B (UVB)-induced systemic lupus erythaematosus (SLE) skin lesions. METHODS A total of 19 SLE patients and 13 controls were irradiated with two minimal erythaemal doses(MED) of UVB. Subsequently, skin biopsies were analysed (immuno) histologically over 10 days, for expression of IFNalpha-induced MxA, numbers of plasmacytoid dendritic cells (pDC), and… CONTINUE READING