Type I interferons are essential mediators of apoptotic death in virally infected cells.

@article{Tanaka1998TypeII,
  title={Type I interferons are essential mediators of apoptotic death in virally infected cells.},
  author={Nobuyuki Tanaka and Masahiro Sato and Marc S. Lamphier and Hiroshi Nozawa and Eri Oda and Shinzaburo Noguchi and Robert D Schreiber and Yoshihide Tsujimoto and T. Taniguchi},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={1998},
  volume={3 1},
  pages={
          29-37
        }
}
BACKGROUND The interferons (IFNs) have been extensively studied in the context of host defence against viral infection. In the established model of IFN action, virally infected cells secrete type I IFNs (IFN-alpha/beta) which induce an antiviral state in uninfected cells. However, it is not clear how IFNs function on the infected cells. It has been reported that cells infected by some viruses die by apoptosis. RESULTS In the present study, we found that three types of viruses commonly induce… CONTINUE READING
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