Type I interferons are essential in controlling neurotropic coronavirus infection irrespective of functional CD8 T cells.

@article{Ireland2008TypeII,
  title={Type I interferons are essential in controlling neurotropic coronavirus infection irrespective of functional CD8 T cells.},
  author={Derek D C Ireland and Stephen A. Stohlman and David R Hinton and Roscoe A. Atkinson and Cornelia C. Bergmann},
  journal={Journal of virology},
  year={2008},
  volume={82 1},
  pages={300-10}
}
Neurotropic coronavirus infection induces expression of both beta interferon (IFN-beta) RNA and protein in the infected rodent central nervous system (CNS). However, the relative contributions of type I IFN (IFN-I) to direct, cell-type-specific virus control or CD8 T-cell-mediated effectors in the CNS are unclear. IFN-I receptor-deficient (IFNAR(-/-)) mice infected with a sublethal and demyelinating neurotropic virus variant and those infected with a nonpathogenic neurotropic virus variant both… CONTINUE READING