Type I interferons: ancient peptides with still under-discovered anti-cancer properties.

@article{Caraglia2013TypeII,
  title={Type I interferons: ancient peptides with still under-discovered anti-cancer properties.},
  author={Michele Caraglia and Alessandra Dicitore and Monica Marra and Sara Castiglioni and Luca Persani and Pasquale Sperlongano and Pierosandro Tagliaferri and Alberto Abbruzzese and Giovanni Vitale},
  journal={Protein and peptide letters},
  year={2013},
  volume={20 4},
  pages={
          412-23
        }
}
Type I interferons (IFNs) represent a group of cytokines that act through a common receptor composed by two chains (IFNAR-1 and IFNAR-2). Several in vitro and in vivo studies showed a potent antitumor activity induced by these cytokines. IFN-α, the first cytokine to be produced by recombinant DNA technology, has emerged as an important regulator of cancer cell growth and differentiation, affecting cellular communication and signal transduction pathways. IFN-α, is currently the most used… CONTINUE READING

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