Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses.

@article{Teles2013TypeII,
  title={Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses.},
  author={Rosane M B Teles and Thomas G Graeber and Stephan R. Krutzik and Dennis P Montoya and Mirjam Schenk and Delphine J. Lee and Evangelia Komisopoulou and Kindra M Kelly-Scumpia and Rene F. Chun and Shankar Subramanian Iyer and Euzenir Nunes Sarno and Thomas H. C. Rea and Martin Hewison and J. J. Adams and Stephen J Popper and David A. Relman and Steffen Stenger and Barry R. Bloom and Genhong Cheng and Robert L Modlin},
  journal={Science},
  year={2013},
  volume={339 6126},
  pages={1448-53}
}
Type I interferons (IFN-α and IFN-β) are important for protection against many viral infections, whereas type II interferon (IFN-γ) is essential for host defense against some bacterial and parasitic pathogens. Study of IFN responses in human leprosy revealed an inverse correlation between IFN-β and IFN-γ gene expression programs. IFN-γ and its downstream vitamin D-dependent antimicrobial genes were preferentially expressed in self-healing tuberculoid lesions and mediated antimicrobial activity… CONTINUE READING
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