Type I interferon signature is high in lupus and neuromyelitis optica but low in multiple sclerosis.

@article{Feng2012TypeII,
  title={Type I interferon signature is high in lupus and neuromyelitis optica but low in multiple sclerosis.},
  author={Xuan Feng and Nicholas P. Reder and Mounica Yanamandala and Addie Hill and Beverly S. Franek and Timothy B Niewold and Anthony T. Reder and Adil Javed},
  journal={Journal of the neurological sciences},
  year={2012},
  volume={313 1-2},
  pages={48-53}
}
OBJECTIVE Neuromyelitis optica (NMO) is characterized by selective inflammation of the spinal cord and optic nerves but is distinct from multiple sclerosis (MS). Interferon (IFN)-β mitigates disease activity in MS, but is controversial in NMO, with a few reports of disease worsening after IFN-β therapy in this highly active disease. In systemic lupus erythematosus (SLE), IFNs adversely affect disease activity. This study examines for the first time whether serum IFN-α/β activity and IFN… CONTINUE READING
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