Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10

@inproceedings{KellyScumpia2010TypeII,
  title={Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10},
  author={Kindra M Kelly-Scumpia and Philip O Scumpia and Matthew J. Delano and Jason Scott Weinstein and Alex Gervacio Cuenca and James L Wynn and Lyle L. Moldawer},
  booktitle={The Journal of experimental medicine},
  year={2010}
}
Type I interferon (IFN) alpha/beta is critical for host defense. During endotoxicosis or highly lethal bacterial infections where systemic inflammation predominates, mice deficient in IFN-alpha/beta receptor (IFNAR) display decreased systemic inflammation and improved outcome. However, human sepsis mortality often occurs during a prolonged period of immunosuppression and not from exaggerated inflammation. We used a low lethality cecal ligation and puncture (CLP) model of sepsis to determine the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 61 CITATIONS

FILTER CITATIONS BY YEAR

2011
2019

CITATION STATISTICS

  • 4 Highly Influenced Citations

  • Averaged 5 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 21 REFERENCES

Similar Papers

Loading similar papers…