Type I interferon response in the central nervous system.

@article{Paul2007TypeII,
  title={Type I interferon response in the central nervous system.},
  author={Sophie Paul and C{\'e}line Ricour and Caroline Sommereyns and Fr{\'e}d{\'e}ric Sorgeloos and Thomas Michiels},
  journal={Biochimie},
  year={2007},
  volume={89 6-7},
  pages={
          770-8
        }
}
This review is dedicated to the influence of type I IFNs (also called IFN-alpha/beta) in the central nervous system (CNS). Studies in mice with type I IFN receptor or IFN-beta gene deficiency have highlighted the importance of the type I IFN system against CNS viral infections and non-viral autoimmune disorders. Direct antiviral effects of type I IFNs appear to be crucial in limiting early spread of a number of viruses in CNS tissues. Type I IFNs have also proved to be beneficial in autoimmune… CONTINUE READING

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