Type I interferon response against viral and non-viral gene transfer in human tumor and primary cell lines.

@article{Rautsi2007TypeII,
  title={Type I interferon response against viral and non-viral gene transfer in human tumor and primary cell lines.},
  author={Outi Rautsi and Saara Lehmusvaara and Tuula Salonen and Katja H{\"a}kkinen and Maarit Sillanp{\"a}{\"a} and Tanja Hakkarainen and Sami Heikkinen and Elisa V{\"a}h{\"a}kangas and Seppo Yl{\"a}-Herttuala and A. E. Hinkkanen and Ilkka Julkunen and Jarmo Wahlfors and Riikka Pellinen},
  journal={The journal of gene medicine},
  year={2007},
  volume={9 2},
  pages={122-35}
}
BACKGROUND Type I interferon (IFN-alpha/beta) response is one of the major host defence mechanisms against viruses. Some recent reports suggest that IFNs may interfere with the efficacy of both non-viral and virus-vector-mediated therapeutic gene transfer. METHODS The type I IFN response upon different gene transfer methods in human tumor and primary cell lines was studied by analysing IFN-beta mRNA expression, secretion of type I IFNs and accumulation of IFN-alpha/beta-induced MxA protein… CONTINUE READING

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