Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity.

  title={Type I interferon protects antiviral CD8+ T cells from NK cell cytotoxicity.},
  author={H C Xu and Melanie Grusdat and Aleksandra A. Pandyra and Robin Polz and Jun Huang and Piyush Sharma and Ren{\'e} Deenen and Karl K{\"o}hrer and Ramtin Rahbar and Andreas Diefenbach and Kathrin Gibbert and Max L{\"o}hning and Lena H{\"o}cker and Zoe Waibler and Dieter H{\"a}ussinger and Tak W Mak and Pamela S Ohashi and Karl S Lang and Philipp A. Lang},
  volume={40 6},
Despite development of new antiviral drugs, viral infections are still a major health problem. The most potent antiviral defense mechanism is the innate production of type I interferon (IFN-I), which not only limits virus replication but also promotes antiviral T cell immunity through mechanisms, which remain insufficiently studied. Using the murine lymphocytic choriomeningitis virus model system, we show here that IFN-I signaling on T cells prevented their rapid elimination in vivo. Microarray… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 8 times over the past 90 days. VIEW TWEETS