Type I interferon production by nucleic acid-stimulated dendritic cells.

@article{Kaisho2008TypeII,
  title={Type I interferon production by nucleic acid-stimulated dendritic cells.},
  author={Tsuneyasu Kaisho},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2008},
  volume={13},
  pages={6034-42}
}
  • Tsuneyasu Kaisho
  • Published 2008 in
    Frontiers in bioscience : a journal and virtual…
Dendritic cells (DC) detect nucleic acid adjuvants through the Toll-like receptor (TLR) or cytosolic sensors. Nucleic acid adjuvants activate DC to produce a variety of soluble factors including proinflammatory cytokines or type I interferons (IFNs). Type I IFN, especially IFN-alpha, induction is a characteristic function of nucleic acid adjuvants and critical for antiviral host defense. Notably, nucleic acids derived from the host as well as from the pathogens can function as immune adjuvants… CONTINUE READING

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