Type I interferon limits influenza virus-induced acute lung injury by regulation of excessive inflammation in mice.

@article{Arimori2013TypeII,
  title={Type I interferon limits influenza virus-induced acute lung injury by regulation of excessive inflammation in mice.},
  author={Yojiro Arimori and Risa Nakamura and Hisakata Yamada and Kensuke Shibata and Naoyoshi Maeda and Tetsuo Kase and Yasunobu Yoshikai},
  journal={Antiviral research},
  year={2013},
  volume={99 3},
  pages={230-7}
}
Antiviral immune responses play as a double edged sword in resolution of infection and pathogenesis of acute lung injury caused by infection with highly pathogenic influenza A viruses. Here we show that type I interferons (IFNs) are important in protection against acute influenza A virus infection not only via their antiviral activity but also via their anti-inflammatory activity. IFN α receptor (IFNAR) knock-out (KO) mice exhibited increased mortality and morbidity with higher viral load after… CONTINUE READING
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