Type I interferon is a therapeutic target for virus-induced lethal vascular damage.

@article{Baccala2014TypeII,
  title={Type I interferon is a therapeutic target for virus-induced lethal vascular damage.},
  author={Roberto Baccala and Megan J. Welch and Rosana Gonzalez-Quintial and Kevin B Walsh and John R Teijaro and Anthony P. Nguyen and Cherie T. Ng and Brian M. Sullivan and Alessandro Zarpellon and Zaverio M. Ruggeri and Juan C de la Torre and Argyrios N. Theofilopoulos and Michael B A Oldstone},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 24},
  pages={8925-30}
}
The outcome of a viral infection reflects the balance between virus virulence and host susceptibility. The clone 13 (Cl13) variant of lymphocytic choriomeningitis virus--a prototype of Old World arenaviruses closely related to Lassa fever virus--elicits in C57BL/6 and BALB/c mice abundant negative immunoregulatory molecules, associated with T-cell exhaustion, negligible T-cell-mediated injury, and high virus titers that persist. Conversely, here we report that in NZB mice, despite the efficient… CONTINUE READING
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