Type I interferon inhibits antibody responses induced by a chimpanzee adenovirus vector.

@article{Hensley2007TypeII,
  title={Type I interferon inhibits antibody responses induced by a chimpanzee adenovirus vector.},
  author={Scott E Hensley and Ann S Cun and Wynetta Giles-Davis and Yan Li and Zhiquan Xiang and Marcio de Oliveira Lasaro and Bryan Raymond George Williams and Robert H. Silverman and Hildegund C. J. Ertl},
  journal={Molecular therapy : the journal of the American Society of Gene Therapy},
  year={2007},
  volume={15 2},
  pages={393-403}
}
Recent studies have indicated that type I interferon (IFN) enhances antibody responses and promotes isotype switching. In this study, we analyzed the role of type I IFN signaling during the generation of transgene product-specific antibody responses elicited by recombinant adenovirus (Ad) vectors. A vector derived from a human Ad serotype (AdHu5) induced low levels of type I IFN following infection of dendritic cells (DCs) and stimulated normal transgene product-specific antibody responses in… CONTINUE READING

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