Type I interferon dysregulation and neurological disease

@article{McGlasson2015TypeII,
  title={Type I interferon dysregulation and neurological disease},
  author={Sarah L McGlasson and Alexa Jury and Andrew Jackson and David P J Hunt},
  journal={Nature Reviews Neurology},
  year={2015},
  volume={11},
  pages={515-523}
}
Type I interferon is an essential component of the brain's innate immune defence, conferring protection against viral infection. Recently, dysregulation of the type I interferon pathway has been implicated in the pathogenesis of a spectrum of neuroinfectious and neuroinflammatory disorders. Underactivity of the type I interferon response is associated with a predisposition to herpes simplex encephalitis. Conversely, a group of 'interferonopathic' disorders, characterized by severe… 
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