Type I interferon and Toll-like receptor expression characterizes inflammatory myopathies.

@article{Cappelletti2011TypeII,
  title={Type I interferon and Toll-like receptor expression characterizes inflammatory myopathies.},
  author={Cristina Cappelletti and Fulvio Baggi and Francesca Zolezzi and Donatella Biancolini and Ottavio Beretta and Martina Severa and Eliana M Coccia and Paolo Confalonieri and Lucia Morandi and Marina Mora and Renato Mantegazza and Pia Bernasconi},
  journal={Neurology},
  year={2011},
  volume={76 24},
  pages={
          2079-88
        }
}
OBJECTIVES Juvenile dermatomyositis (JDM), adult dermatomyositis, and polymyositis (PM) are idiopathic inflammatory myopathies (IIMs) characterized by muscle infiltration and specific muscle fiber alterations. They are thought to have an autoimmune etiology, but triggering factors, and how immunologic attack induces muscle weakness, remain unknown. Recent evidence suggests a key role for type I interferon (IFN)-mediated innate immunity in dermatomyositis, which we explored in JDM… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 41 CITATIONS

Current Classification and Management of Inflammatory Myopathies

  • Journal of neuromuscular diseases
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND