Type I collagen receptor (alpha2beta1) signaling promotes prostate cancer invasion through RhoC GTPase.

@article{Hall2008TypeIC,
  title={Type I collagen receptor (alpha2beta1) signaling promotes prostate cancer invasion through RhoC GTPase.},
  author={Christopher L. Hall and Cara W. Dubyk and Tracy A. Riesenberger and Daniel Shein and Evan Keller and Kenneth L. van Golen},
  journal={Neoplasia},
  year={2008},
  volume={10 8},
  pages={797-803}
}
The most frequent site of metastasis in human prostate cancer (PCa) is the bone. Preferential adhesion of PCa cells to bone-specific factors may facilitate the selective metastasis of the skeleton. The most abundant protein within the skeleton is type I collagen. We previously demonstrated that PCa cells selected in vitro for collagen I binding (LNCaP(col)) are highly motile and acquired the capacity to grow within the bone compared to nontumorigenic LNCaP parental cells. Treatment with alpha(2… CONTINUE READING

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