Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma.

  title={Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma.},
  author={Thomas A Armstrong and Graham K. Packham and Lindsay B Murphy and Adrian C Bateman and John A Conti and David Roger Fine and Colin David Johnson and Robert Christopher Benyon and John Peter Iredale},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={10 21},
PURPOSE The purpose of this study was to determine the role of functional interactions between pancreatic cancer cells and pancreatic stellate cells (PSCs) in the formation of the desmoplastic reaction (DR) in pancreatic cancer and to characterize the effect of type I collagen (the predominant component of the DR) on pancreatic cancer cell phenotype. EXPERIMENTAL DESIGN PSCs and type I collagen were identified in sections of pancreatic cancer using immunohistochemistry, and their anatomic… CONTINUE READING
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