Type I collagen inhibits differentiation and promotes a stem cell-like phenotype in human colorectal carcinoma cells

@article{Kirkland2009TypeIC,
  title={Type I collagen inhibits differentiation and promotes a stem cell-like phenotype in human colorectal carcinoma cells},
  author={Susan C. Kirkland},
  journal={British Journal of Cancer},
  year={2009},
  volume={101},
  pages={320 - 326}
}
Background:Human colorectal cancer is caused by mutations and is thought to be maintained by a population of cancer stem cells. Further phenotypic changes occurring at the invasive edge suggest that colon cancer cells are also regulated by their microenvironment. Type I collagen, a promoter of the malignant phenotype in pancreatic carcinoma cells, is highly expressed at the invasive front of human colorectal cancer.Methods:This study investigates the role of type I collagen in specifying the… CONTINUE READING