Type I collagen induces tissue factor expression and matrix metalloproteinase 9 production in human primary monocytes through a redox-sensitive pathway.

@article{Poitevin2008TypeIC,
  title={Type I collagen induces tissue factor expression and matrix metalloproteinase 9 production in human primary monocytes through a redox-sensitive pathway.},
  author={St{\'e}phane Poitevin and Roselyne Garnotel and Frank Antonicelli and Philippe Gillery and Philippe Nguyen},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2008},
  volume={6 9},
  pages={1586-94}
}
BACKGROUND Tissue factor (TF), the main trigger of coagulation cascade, is a major component of the atherosclerotic plaque. Matrix metalloproteinases (MMPs) are recognized as key mediators of extracellular matrix remodeling during inflammation. It was recently emphasized that both TF and MMP-9 were overexpressed in atherosclerotic plaques, suggesting a role of both molecules in plaque instability and thrombogenicity. OBJECTIVE The present study was designed to determine whether human… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Monocyte subsets differentially employ CCR 2 , CCR 5 , and CX 3 CR 1 to accumulate within atherosclerotic plaques

  • F Tacke, D Alvarez, +10 authors GJ Randolph
  • J Clin Invest
  • 2007

Chemokines: key regulators

  • C Weber, A Schober, A. Zernecke
  • 2005

Integrin regulation

  • ST Fan, N Mackman, MZ Cui, TS. Edgington
  • studies and clinical outcomes. J Thromb Haemost…
  • 2005

Similar Papers

Loading similar papers…