Type I collagen induces tissue factor expression and matrix metalloproteinase 9 production in human primary monocytes through a redox‐sensitive pathway

@article{Poitevin2008TypeIC,
  title={Type I collagen induces tissue factor expression and matrix metalloproteinase 9 production in human primary monocytes through a redox‐sensitive pathway},
  author={S. Poitevin and R. Garnotel and F. Antonicelli and P. Gillery and P. Nguyen},
  journal={Journal of Thrombosis and Haemostasis},
  year={2008},
  volume={6}
}
  • S. Poitevin, R. Garnotel, +2 authors P. Nguyen
  • Published 2008
  • Medicine
  • Journal of Thrombosis and Haemostasis
  • Summary.  Background: Tissue factor (TF), the main trigger of coagulation cascade, is a major component of the atherosclerotic plaque. Matrix metalloproteinases (MMPs) are recognized as key mediators of extracellular matrix remodeling during inflammation. It was recently emphasized that both TF and MMP‐9 were overexpressed in atherosclerotic plaques, suggesting a role of both molecules in plaque instability and thrombogenicity. Objective: The present study was designed to determine whether… CONTINUE READING
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