Type I collagen down-regulates E-cadherin expression by increasing PI3KCA in cancer cells.

@article{Cheng2011TypeIC,
  title={Type I collagen down-regulates E-cadherin expression by increasing PI3KCA in cancer cells.},
  author={Jung-Chien Cheng and Peter C. K. Leung},
  journal={Cancer letters},
  year={2011},
  volume={304 2},
  pages={107-16}
}
The extracellular matrix (ECM) has been shown to induce the epithelial-mesenchymal transition (EMT), which is characterized by the loss of E-cadherin. However, little is known about the mechanisms by which collagen I, the most abundant component of ECM, induces this process. Here, we show that E-cadherin was down-regulated in response to collagen I in SKOV3 ovarian cancer cells and PC3 prostate cancer cells. Furthermore, collagen I induced the up-regulation of PIK3CA, which in turn contributed… CONTINUE READING

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