Type I and type II keratins have evolved from lower eukaryotes to form the epidermal intermediate filaments in mammalian skin.

@article{Fuchs1983TypeIA,
  title={Type I and type II keratins have evolved from lower eukaryotes to form the epidermal intermediate filaments in mammalian skin.},
  author={Elaine Fuchs and Douglas A. Marchuk},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1983},
  volume={80 19},
  pages={5857-61}
}
We have traced the evolutionary origins of keratin-like sequences to the genomes of lower eukaryotes. The proteins encoded by these genes have evolved to form the intermediate filaments that comprise the backbone of vertebrate skin cells. Two related but distinct types of keratins encoded by two separate multigene subfamilies are expressed in the epidermal keratinocytes of vertebrate species from fish to human. Both at the level of protein and at the level of DNA, these two classes of keratins… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 47 extracted citations

Fundamental hair follicle biology and fine fibre production in animals.

Animal : an international journal of animal bioscience • 2010
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…