Type I and type II error rates for quantitative trait loci (QTL) mapping studies using recombinant inbred mouse strains.

Abstract

Effective mapping strategies for quantitative trains must allow for the detection of the more important quantitative trait loci (QTLs) while minimizing false positives. Type I (false-positive) and Type II (false-negative) error rates were estimated from a computer simulation of QTL mapping in the BXD recombinant inbred (RI) set compromising 26 strains of… (More)

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