Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence

@inproceedings{Cunningham2016TypeIA,
  title={Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence},
  author={Cameron R. Cunningham and Ameya Champhekar and Michael V. Tullius and Barbara Jane Dillon and Anjie Zhen and Justin Rafael de la Fuente and Jonathan Herskovitz and Heidi Elsaesser and Laura M. Snell and Elizabeth S B Wilson and Juan C de la Torre and Scott G. Kitchen and Marcus A. Horwitz and Steven J. Bensinger and Stephen T. Smale and David G. Brooks and P. F. Loke},
  booktitle={PLoS pathogens},
  year={2016}
}
Persistent viral infections are simultaneously associated with chronic inflammation and highly potent immunosuppressive programs mediated by IL-10 and PDL1 that attenuate antiviral T cell responses. Inhibiting these suppressive signals enhances T cell function to control persistent infection; yet, the underlying signals and mechanisms that program immunosuppressive cell fates and functions are not well understood. Herein, we use lymphocytic choriomeningitis virus infection (LCMV) to demonstrate… CONTINUE READING
Highly Cited
This paper has 30 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 57 references

A cellular calculus for signal integration by T cells

Nature Immunology • 2000
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…