Type I Interferon Induced Epigenetic Regulation of Macrophages Suppresses Innate and Adaptive Immunity in Acute Respiratory Viral Infection

@inproceedings{Kroetz2015TypeII,
  title={Type I Interferon Induced Epigenetic Regulation of Macrophages Suppresses Innate and Adaptive Immunity in Acute Respiratory Viral Infection},
  author={Danielle N. Kroetz and Ronald M Allen and Matthew A. Schaller and Cleyton Cavallaro and Toshihiro Ito and Steven L. Kunkel and Paul G. Thomas},
  booktitle={PLoS pathogens},
  year={2015}
}
Influenza A virus (IAV) is an airborne pathogen that causes significant morbidity and mortality each year. Macrophages (Mϕ) are the first immune population to encounter IAV virions in the lungs and are required to control infection. In the present study, we explored the mechanism by which cytokine signaling regulates the phenotype and function of Mϕ via epigenetic modification of chromatin. We have found that type I interferon (IFN-I) potently upregulates the lysine methyltransferase Setdb2 in… CONTINUE READING
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