Type I IL-1 receptor blockade exacerbates murine listeriosis.

  title={Type I IL-1 receptor blockade exacerbates murine listeriosis.},
  author={Edward A. Havell and Lyle L. Moldawer and D C Helfgott and Patricia Kilian and Pravin B Sehgal},
  journal={Journal of immunology},
  volume={148 5},
It was found that IL-1 is produced in livers and spleens of mice shortly after the i.v. injection of a sublethal or lethal Listeria monocytogenes inoculum. In sublethally infected mice, IL-1 was present in infected livers and spleens by the end of the first day of infection. Thereafter, the amounts of IL-1 in these organs increased and decreased in concordance with bacterial numbers. IL-1 was not present in the peripheral circulation of mice during sublethal listeriosis, but was present in the… CONTINUE READING

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