Type I IFNs regulate effector and regulatory T cell accumulation and anti-inflammatory cytokine production during T cell-mediated colitis.

@article{Kole2013TypeII,
  title={Type I IFNs regulate effector and regulatory T cell accumulation and anti-inflammatory cytokine production during T cell-mediated colitis.},
  author={Abhisake Kole and Jianping He and Aymeric Marie Christian Rivollier and Danielle Farias da Silveira and Kazuya Kitamura and Kevin J Maloy and Brian Lee Kelsall},
  journal={Journal of immunology},
  year={2013},
  volume={191 5},
  pages={
          2771-9
        }
}
We explored the function of endogenous type I IFNs (IFN-1) in the colon using the T cell adoptive transfer model of colitis. Colon mononuclear phagocytes (MPs) constitutively produced IFN-1 in a Toll/IL-1R domain-containing adapter-inducing IFN-β-dependent manner. Transfer of CD4(+)CD45RB(hi) T cells from wild-type (WT) or IFN-α/β receptor subunit 1 knockout (IFNAR1(-/-)) mice into RAG(-/-) hosts resulted in similar onset and severity of colitis. In contrast, RAG(-/-) × IFNAR1(-/-) double… CONTINUE READING

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