Type I IFN signaling triggers immunopathology in tuberculosis-susceptible mice by modulating lung phagocyte dynamics

@inproceedings{Dorhoi2014TypeII,
  title={Type I IFN signaling triggers immunopathology in tuberculosis-susceptible mice by modulating lung phagocyte dynamics},
  author={Anca Dorhoi and Vladimir Yeremeev and Geraldine Nouailles and January Weiner and Sabine J{\"o}rg and Ellen Heinemann and Dagmar Oberbeck-Mueller and Julia K Knaul and Alexis Vogelzang and Stephen T. Reece and Karin Hahnke and Hans-Joachim Mollenkopf and V Brinkmann and Stefan H. E. Kaufmann},
  booktitle={European journal of immunology},
  year={2014}
}
General interest in the biological functions of IFN type I in Mycobacterium tuberculosis (Mtb) infection increased after the recent identification of a distinct IFN gene expression signature in tuberculosis (TB) patients. Here, we demonstrate that TB-susceptible mice lacking the receptor for IFN I (IFNAR1) were protected from death upon aerogenic infection with Mtb. Using this experimental model to mimic primary progressive pulmonary TB, we dissected the immune processes affected by IFN I… CONTINUE READING
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