Type I IFN controls chikungunya virus via its action on nonhematopoietic cells

  title={Type I IFN controls chikungunya virus via its action on nonhematopoietic cells},
  author={Cl{\'e}mentine Schilte and Th{\'e}r{\'e}se Couderc and Fabrice C Chr{\'e}tien and Marion Sourisseau and Nicolas Gangneux and Florence Guivel-Benhassine and Anton Kraxner and J. -M. Tschopp and Stephen T Higgs and Alain Michault and Fernando Arenzana-Seisdedos and Marco Colonna and Lucie Peduto and Olivier Schwartz and Marc Lecuit and Matthew L Albert},
  booktitle={The Journal of experimental medicine},
Chikungunya virus (CHIKV) is the causative agent of an outbreak that began in La Réunion in 2005 and remains a major public health concern in India, Southeast Asia, and southern Europe. CHIKV is transmitted to humans by mosquitoes and the associated disease is characterized by fever, myalgia, arthralgia, and rash. As viral load in infected patients declines before the appearance of neutralizing antibodies, we studied the role of type I interferon (IFN) in CHIKV pathogenesis. Based on human… CONTINUE READING
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Development of a sensitive real-time reverse transcriptase PCR assay with an internal control to detect and quantify chikungunya virus

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