Type D hepatitis: the clinical significance of hepatitis D virus RNA in serum as detected by a hybridization-based assay.

@article{Smedile1986TypeDH,
  title={Type D hepatitis: the clinical significance of hepatitis D virus RNA in serum as detected by a hybridization-based assay.},
  author={Antonina Smedile and Mario Rizzetto and Katherine J. Denniston and Ferruccio Bonino and F V Wells and Giorgio Verme and Fausto Consolo and Boy Hoyer and Robert H. Purcell and John L. Gerin},
  journal={Hepatology},
  year={1986},
  volume={6 6},
  pages={1297-302}
}
Hepatitis D virus is a defective human pathogen that requires hepatitis B virus for its replication. A hybridization-based assay for the 1.75 kb RNA genome of hepatitis D virus was developed using as probe a radiolabeled transcript of a cloned cDNA fragment (pKD3 hepatitis D virus DNA). Sera from 120 chronic carriers of HBsAg with confirmed hepatitis D virus infection were analyzed for the presence of hepatitis D virus RNA. Serum hepatitis D virus RNA was detected in 43 of 74 (58%) patients… CONTINUE READING
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