Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells

@article{Miyoshi1981TypeCV,
  title={Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells},
  author={I. Miyoshi and I. Kubonishi and S. Yoshimoto and T. Akagi and Y. Ohtsuki and Y. Shiraishi and K. Nagata and Y. Hinuma},
  journal={Nature},
  year={1981},
  volume={294},
  pages={770-771}
}
A recent nationwide survey of the lymphocyte subpopulations of leukaemia and lymphoma in Japan has disclosed a high incidence of adult T-cell leukaemia (ATL)1. One of the striking features of this disease is the clustering of patients in the southwestern part of Japan1,2. We have established a continuous culture line of leukaemic T cells from a patient with ATL3,4. This cell line, MT-1, was found to carry type C virus particles and ATL-associated antigens (ATLA) which specifically reacted with… Expand
Immunoagglutination of type-C virus particles in a human T-cell line by serum supplementation from patients with adult T-cell leukemia
TLDR
Results provide direct evidence for the specific reactivity of ATL patients' sera with type-C virus particles in the MT-2 cell line at the ultrastructural level. Expand
The virus of Japanese adult T-cell leukaemia is a member of the human T-cell leukaemia virus group
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References

SHOWING 1-3 OF 3 REFERENCES
Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma
TLDR
The number of these particle-associated proteins is consistent with the expected proteins of a retrovirus, but the sizes of some are distinct from those of most known retroviruses of the primate subgroups. Expand
Humans have antibodies capable of recognizing oncoviral glycoproteins: demonstration that these antibodies are formed in response to cellular modification of glycoproteins rather than as consequence of exposure to virus.
TLDR
It is shown that antibodies capable of precipitating a wide variety of oncoviral glycoproteins can be demonstrated under certain assay conditions, and the findings not only demonstrate that the antibodies were directed against cellular rather than the virus-coded antigenic determinants but also exclude the possibility that this immune response was elicited as a consequence ofoncovirus exposure. Expand