Corpus ID: 40551002

Type B Insulin Resistance Syndrome as an H. Pylori- Associated Autoimmune

@inproceedings{Katagiri2014TypeBI,
  title={Type B Insulin Resistance Syndrome as an H. Pylori- Associated Autoimmune},
  author={H. Katagiri and Tetsuya Yamada and J. Satoh},
  year={2014}
}
Type B insulin resistance syndrome (IRS) is characterised by production of autoantibodies against the insulin receptor (IR. [...] Key Result In one case, eradication of Helicobacter pylori (HP), aimed at treating ITP, cured type B IRS. In the other case, anti-IR and anti-platelet antibodies were detected only during pregnancy, and after delivery, these autoantibodies and hypoglycemic symptoms disappeared.Expand
Clinical Features of Type B Insulin Resistance in Japanese Patients: Case Report and Survey-Based Case Series Study
TLDR
A case of TBIR that developed 6 months after DPP-4 inhibitor administration and immediately after the patient caught a cold was described, and treatment using prednisolone and insulin-like growth factor-1 was effective. Expand

References

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TLDR
Standardized treatment with rituximab, cyclophosphamide, and pulse steroids results in remission of type B insulin resistance, and future studies will determine whether this treatment protocol can be applied to other autoantibody/cell surface receptor disease states. Expand
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TLDR
It is concluded that IGF-1 therapy was an effective treatment choice for type B insulin-resistance syndrome in cases whose plasma exchange and immunosuppressive therapy have failed. Expand
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TLDR
The case of type B insulin resistance with atypical features is reported, with a 44-year-old white male with a 22-year history of poorly controlled diabetes referred to us with severe Graves ophthalmopathy, who developed marked hypoglycaemia within 24 hours of starting intravenous immunoglobulin treatment. Expand
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TLDR
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TLDR
After immunosuppressive therapy for eight months, the diabetic syndrome disappeared completely and anti-receptor antibodies in the serum were no longer detectable and insulin sensitivity returned to normal, however, the patient's glucose tolerance deteriorated after the temporary termination of cyclophosphamide treatment and the lowering of prednisolone dosage. Expand
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TLDR
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TLDR
Although the evidence and follow-up are limited, it appears reasonable to routinely screen patients with ITP for H pylori, particularly in those populations with a high background prevalence of H Pylori infection. Expand
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TLDR
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