Corpus ID: 40551002

Type B Insulin Resistance Syndrome as an H. Pylori- Associated Autoimmune

  title={Type B Insulin Resistance Syndrome as an H. Pylori- Associated Autoimmune},
  author={H. Katagiri and Tetsuya Yamada and J. Satoh},
Type B insulin resistance syndrome (IRS) is characterised by production of autoantibodies against the insulin receptor (IR. [...] Key Result In one case, eradication of Helicobacter pylori (HP), aimed at treating ITP, cured type B IRS. In the other case, anti-IR and anti-platelet antibodies were detected only during pregnancy, and after delivery, these autoantibodies and hypoglycemic symptoms disappeared.Expand
Clinical Features of Type B Insulin Resistance in Japanese Patients: Case Report and Survey-Based Case Series Study
A case of TBIR that developed 6 months after DPP-4 inhibitor administration and immediately after the patient caught a cold was described, and treatment using prednisolone and insulin-like growth factor-1 was effective. Expand


Treatment of type B insulin resistance: a novel approach to reduce insulin receptor autoantibodies.
Standardized treatment with rituximab, cyclophosphamide, and pulse steroids results in remission of type B insulin resistance, and future studies will determine whether this treatment protocol can be applied to other autoantibody/cell surface receptor disease states. Expand
Clinical efficacy of insulin-like growth factor-1 in a patient with autoantibodies to insulin receptors: a case report.
It is concluded that IGF-1 therapy was an effective treatment choice for type B insulin-resistance syndrome in cases whose plasma exchange and immunosuppressive therapy have failed. Expand
Treatment of type B insulin resistance with immunoglobulin: novel use of an old therapy
The case of type B insulin resistance with atypical features is reported, with a 44-year-old white male with a 22-year history of poorly controlled diabetes referred to us with severe Graves ophthalmopathy, who developed marked hypoglycaemia within 24 hours of starting intravenous immunoglobulin treatment. Expand
Atypical antiinsulin receptor antibodies in a patient with type B insulin resistance and scleroderma.
In a series of 21 patients, this is the first patient with antireceptor antibodies that bound to the insulin receptor without inhibiting insulin binding, and the titer of serum antiresceptor antibody fell to less than 1% of the previous level. Expand
Regression of acanthosis nigricans correlates with disappearance of anti-insulin receptor autoantibodies and achievement of euglycemia in type B insulin resistance syndrome.
It is documented, for the first time, regression of AN in temporal association with disappearance of circulating anti-insulin receptor autoantibodies and achievement of euglycemia in a patient with type B insulin resistance. Expand
Successful immunosuppressive therapy in insulin resistant diabetes caused by anti-insulin receptor autoantibodies.
After immunosuppressive therapy for eight months, the diabetic syndrome disappeared completely and anti-receptor antibodies in the serum were no longer detectable and insulin sensitivity returned to normal, however, the patient's glucose tolerance deteriorated after the temporary termination of cyclophosphamide treatment and the lowering of prednisolone dosage. Expand
A patient with type B insulin resistance syndrome, responsive to immune therapy
A 55-year-old woman with vitiligo, hypothyroidism, interstitial lung disease and diabetes mellitus developed severe insulin resistance during a hospital admission for respiratory failure and was diagnosed with pneumonia due to Pseudomonas aeruginosa. Expand
Helicobacter pylori and Chronic ITP.
  • R. Stasi, D. Provan
  • Medicine
  • Hematology. American Society of Hematology. Education Program
  • 2008
Although the evidence and follow-up are limited, it appears reasonable to routinely screen patients with ITP for H pylori, particularly in those populations with a high background prevalence of H Pylori infection. Expand
The evolving clinical course of patients with insulin receptor autoantibodies: spontaneous remission or receptor proliferation with hypoglycemia.
Three patients with insulin resistance caused by autoantibodies to the insulin receptor were investigated serially over a 3-yr period, demonstrating that patients with antibodies to insulin receptors may have a fluctuating clinical course. Expand
The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man.
In six patients with acanthosis nigricans variable degrees of glucose intolerance, hyperinsulinemia and marked resistance to exogenous insulin were found. Studies of insulin receptors on circulatingExpand