Type AII lantibiotic bovicin HJ50 with a rare disulfide bond: structure, structure-activity relationships and mode of action.

@article{Zhang2014TypeAL,
  title={Type AII lantibiotic bovicin HJ50 with a rare disulfide bond: structure, structure-activity relationships and mode of action.},
  author={Jie Zhang and Yingang Feng and Kunling Teng and Yuheng Lin and Yong Gao and Jin-Feng Wang and Jin Zhong},
  journal={The Biochemical journal},
  year={2014},
  volume={461 3},
  pages={497-508}
}
Lantibiotics are ribosomally synthesized antimicrobial peptides containing unusual amino acids. As promising alternatives to conventional antibiotics, they have a high potential for alleviating the problem of emergent antibiotic resistance, with possible applications in many industries that have antibacterial demand. Bovicin HJ50 is a type AII lantibiotic, the largest group of lantibiotics, comprising a linear N-terminal region and a globular C-terminal region. Interestingly, bovicin H50 has a… CONTINUE READING