Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway.

@article{Lai2013Type5A,
  title={Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway.},
  author={Lo Lai and Lin Yan and Shumin Gao and Che-Lin Hu and Hui Ge and Amy Davidow and Misun Park and Claudio Bravo and Kousaku Iwatsubo and Yoshihiro Ishikawa and Johan Auwerx and David A Sinclair and Stephen F. Vatner and Dorothy E. Vatner},
  journal={Circulation},
  year={2013},
  volume={127 16},
  pages={1692-701}
}
BACKGROUND For reasons that remain unclear, whether type 5 adenylyl cyclase (AC5), 1 of 2 major AC isoforms in heart, is protective or deleterious in response to cardiac stress is controversial. To reconcile this controversy we examined the cardiomyopathy induced by chronic isoproterenol in AC5 transgenic (Tg) mice and the signaling mechanisms involved… CONTINUE READING