Type 5 Adenylyl Cyclase Disruption Increases Longevity and Protects Against Stress

  title={Type 5 Adenylyl Cyclase Disruption Increases Longevity and Protects Against Stress},
  author={Lin Yan and Dorothy E. Vatner and James Patrick O'Connor and Andreas S. Ivessa and Hui Ge and Wei Chen and Shinichi Hirotani and Yoshihiro Ishikawa and Junichi Sadoshima and Stephen F. Vatner},
Mammalian models of longevity are related primarily to caloric restriction and alterations in metabolism. We examined mice in which type 5 adenylyl cyclase (AC5) is knocked out (AC5 KO) and which are resistant to cardiac stress and have increased median lifespan of approximately 30%. AC5 KO mice are protected from reduced bone density and susceptibility to fractures of aging. Old AC5 KO mice are also protected from aging-induced cardiomyopathy, e.g., hypertrophy, apoptosis, fibrosis, and… CONTINUE READING
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