Type 3 deiodinase is critical for the maturation and function of the thyroid axis.

@article{Hernndez2006Type3D,
  title={Type 3 deiodinase is critical for the maturation and function of the thyroid axis.},
  author={Arturo Hern{\'a}ndez and Michael E. Martinez and Steven Fiering and Valerie Anne Galton and Donald L St Germain},
  journal={The Journal of clinical investigation},
  year={2006},
  volume={116 2},
  pages={
          476-84
        }
}
Developmental exposure to appropriate levels of thyroid hormones (THs) in a timely manner is critical to normal development in vertebrates. Among the factors potentially affecting perinatal exposure of tissues to THs is type 3 deiodinase (D3). This enzyme degrades THs and is highly expressed in the pregnant uterus, placenta, and fetal and neonatal tissues. To determine the physiological role of D3, we have generated a mouse D3 knockout model (D3KO) by a targeted inactivating mutation of the… CONTINUE READING

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The Type 3 Deiodinase: Epigenetic Control of Brain Thyroid Hormone Action and Neurological Function

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