Type 2 rhinovirus infection of cultured human tracheal epithelial cells: role of LDL receptor.

@article{Suzuki2001Type2R,
  title={Type 2 rhinovirus infection of cultured human tracheal epithelial cells: role of LDL receptor.},
  author={Takahiro Suzuki and Mutsuo Yamaya and Masato Kamanaka and Yu Jia and Katsutoshi Nakayama and Masayoshi Hosoda and Norihiro Yamada and Hidekazu Nishimura and Kiyohisa Sekizawa and Hidetada Sasaki},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2001},
  volume={280 3},
  pages={L409-20}
}
To examine the role of the low-density lipoprotein (LDL) receptor on minor group human rhinovirus (RV) infection, primary cultures of human tracheal epithelial cells were infected with a minor group (RV2) or a major group (RV14) RV. Viral infection was confirmed by showing with PCR that viral titers in supernatants and lysates from infected cells increased with time. RV2 and RV14 increased expression of mRNA and protein of the LDL receptor on the cells and the cytokine production. RV2 induced… CONTINUE READING
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