Type 2 responses at the interface between immunity and fat metabolism.

@article{Odegaard2015Type2R,
  title={Type 2 responses at the interface between immunity and fat metabolism.},
  author={Justin I. Odegaard and Ajay Chawla},
  journal={Current opinion in immunology},
  year={2015},
  volume={36},
  pages={67-72}
}
Adipose tissue resident leukocytes are often cast solely as the effectors of obesity and its attendant pathologies; however, recent observations have demonstrated that these cells support and effect 'healthy' physiologic function as well as pathologic dysfunction. Importantly, these two disparate outcomes are underpinned by similarly disparate immune programs; type 2 responses instruct and promote metabolic normalcy, while type 1 responses drive tissue dysfunction. In this Review, we summarize… CONTINUE READING