Type 2 iodothyronine deiodinase is upregulated in rat slow- and fast-twitch skeletal muscle during cold exposure.

@article{Louzada2014Type2I,
  title={Type 2 iodothyronine deiodinase is upregulated in rat slow- and fast-twitch skeletal muscle during cold exposure.},
  author={Ruy Andrade N. Louzada and Maria Carolina de Souza Santos and Jo{\~a}o Paulo Cavalcanti-de-Albuquerque and Igor F Rangel and Andrea C F Ferreira and Ant{\^o}nio Galina and Jo{\~a}o Pedro Saar Werneck-de-castro and Denise P Carvalho},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2014},
  volume={307 11},
  pages={
          E1020-9
        }
}
During cold acclimation, shivering is progressively replaced by nonshivering thermogenesis. Brown adipose tissue (BAT) and skeletal muscle are relevant for nonshivering thermogenesis, which depends largely on thyroid hormone. Since the skeletal muscle fibers progressively adapt to cold exposure through poorly defined mechanisms, our intent was to determine whether skeletal muscle type 2 deiodinase (D2) induction could be implicated in the long-term skeletal muscle cold acclimation. We… CONTINUE READING

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