Type 2 iodothyronine deiodinase is essential for thyroid hormone-dependent embryonic development and pigmentation in zebrafish.

@article{Walpita2009Type2I,
  title={Type 2 iodothyronine deiodinase is essential for thyroid hormone-dependent embryonic development and pigmentation in zebrafish.},
  author={Chaminda Niroshan Walpita and Alexander D. Crawford and Els D R Janssens and Serge van der Geyten and Veerle M. Darras},
  journal={Endocrinology},
  year={2009},
  volume={150 1},
  pages={530-9}
}
Despite the known importance of thyroid hormones (THs) in vertebrate growth and development, the role of tissue-specific TH activation in early embryogenesis remains unclear. We therefore examined the function of type 2 iodothyronine deiodinase (D2), one of the two tissue-specific enzymes catalyzing the conversion of T4 to T3, in developing zebrafish embryos (Danio rerio). Microinjection of early embryos with antisense oligonucleotides targeting either the D2 translation start site or the… CONTINUE READING

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