Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator-inducible T-cell costimulator ligand interaction.

@article{Rigas2017Type2I,
  title={Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator-inducible T-cell costimulator ligand interaction.},
  author={Diamanda Rigas and Gavin M Lewis and Jennifer L. Aron and Bowen Wang and Homayon Banie and Ishwarya Sankaranarayanan and Lauriane Galle-Treger and Hadi Maazi and Richard Houa-Gong Lo and Gordon J Freeman and Arlene H Sharpe and Pejman Soroosh and Omid Akbari},
  journal={The Journal of allergy and clinical immunology},
  year={2017},
  volume={139 5},
  pages={1468-1477.e2}
}
BACKGROUND Atopic diseases, including asthma, exacerbate type 2 immune responses and involve a number of immune cell types, including regulatory T (Treg) cells and the emerging type 2 innate lymphoid cells (ILC2s). Although ILC2s are potent producers of type 2 cytokines, the regulation of ILC2 activation and function is not well understood. OBJECTIVE In the present study, for the first time, we evaluate how Treg cells interact with pulmonary ILC2s and control their function. METHODS ILC2s… CONTINUE READING

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