Type 2 innate lymphocytes in allergic airway inflammation.

  title={Type 2 innate lymphocytes in allergic airway inflammation.},
  author={Roel G.J. Klein Wolterink and Rudi W Hendriks},
  journal={Current allergy and asthma reports},
  volume={13 3},
CD4(+) T helper-2 (Th2) cells, which produce a unique profile of IL-4, IL-5 and IL-13 pro-inflammatory cytokines, are thought to be central in the orchestration and amplification of allergic asthma. However, a novel non-T/non-B lymphoid cell population, named type 2 innate lymphocytes (ILC2s), that produces high amounts of IL-5 and IL-13 was recently discovered. Unlike Th2 cells, these ILC2s are not antigen-restricted and are activated by epithelial cell-derived cytokines IL-25 and IL-33. In… CONTINUE READING