Type 2 helper T-cell predominance and high CD30 expression in systemic sclerosis.

@article{Mavalia1997Type2H,
  title={Type 2 helper T-cell predominance and high CD30 expression in systemic sclerosis.},
  author={C Mavalia and Cristina Scaletti and Paola Romagnani and Anna Maria Carossino and Alberto Pignone and Lorenzo Emmi and Cinzia Pupilli and Giovanni Pizzolo and Enrico Maggi and Sergio Romagnani},
  journal={The American journal of pathology},
  year={1997},
  volume={151 6},
  pages={
          1751-8
        }
}
The pattern of cytokine production of skin-infiltrating T cells from patients with progressive systemic sclerosis was investigated. Most CD4+ T-cell clones generated from skin biopsy specimens showed a type 2 helper (Th2) cytokine profile (production of interleukin-4, but no interferon (IFN)-gamma). High interleukin-4 but little or no IFN-gamma mRNA expression was found by in situ hybridization in skin perivascular mononuclear cell infiltrates. The immunohistochemical analysis revealed CD30… CONTINUE READING

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