Type 2 diabetes mellitus: a metabolic autoinflammatory disease.

@article{MandrupPoulsen2013Type2D,
  title={Type 2 diabetes mellitus: a metabolic autoinflammatory disease.},
  author={Thomas Mandrup-Poulsen},
  journal={Dermatologic clinics},
  year={2013},
  volume={31 3},
  pages={495-506}
}
The recent molecular, biologic, and genetic understanding of the inflammasome has revolutionized the diagnosis of and therapy for the phenotypically heterogeneous group of rare oligogenic disorders, now recognized to have autoinflammatory origin. This article reviews the importance of inflammasome activation in the central and peripheral mechanisms underlying a common, multifactorial, lifestyle-related, and polygenetic disease (type 2 diabetes mellitus), and conceptualizes the notion that this… CONTINUE READING