Type 2 diabetes as a redox disease

@article{Watson2014Type2D,
  title={Type 2 diabetes as a redox disease},
  author={James D. Watson},
  journal={The Lancet},
  year={2014},
  volume={383},
  pages={841-843}
}
—and physical exercise seem to be benefi cial for several of the same diseases, including cancer, Alzheimer’s disease, and cardiovascular disease. 5,6 New evidence 7 shows that combinations of short-term metformin treatment with single acute bouts of exercise do not, as generally expected, enhance insulin sensitivity. In fact, metformin alone can attenuate much of the oxidative eff ect of exercise. 7 
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Oxidative Stress and Cardiovascular Risk in Type 1 Diabetes Mellitus: Insights From the DCCT/EDIC Study
  • W. Tang, P. McGee, +549 authors K. McVary
  • Medicine
  • Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
  • 2018
TLDR
Higher paraoxonase activity, reflective of antioxidant activity, and 2,3 dinor‐8 iso prostaglandin F2α, an oxidative marker, were significantly associated with lower risk of cardiovascular disease, but these biomarkers did not change over time with intensification of glycemic control. Expand
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